Human CD31 / PECAM1 Protein
CD31,CD31/EndoCAM,endoCAM,GPIIA',PECA1,PECAM-1
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| Catalog Number | P10148-HCCH |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD31,CD31/EndoCAM,endoCAM,GPIIA',PECA1,PECAM-1 |
| Molecular Weight | The recombinant human CD31 consists of 580 amino acids and has a predicted molecular mass of 65.1 kDa. As a result of glycosylation, the molecular mass of rhCD31 is approximately 115 kDa in SDS-PAGE. |
| predicted N | Gln 28 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | The mature form of human CD31 (EAW94208.1) extracellular domain (Met1-Lys 601) with five additional amino acids (DDDDK) at the C-terminus was expressed and purified. |
| Bio-activity | |
| Research Area | Developmental Biology |Embryogenesis |Germ Layer Formation |Mesoderm Marker |
| Formulation | Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | The Cluster of Differentiation 31 (CD31) adhesion molecule, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1), is the only known member of the CAM family on platelets. CD31 protein is a 130-kDa transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets. CD31 protein is also expressed in certain tumors, including epithelioid hemangioendothelioma, other vascular tumors, and histiocytic malignancies. CD31 plays a key role in removing aged neutrophils and tissue regeneration. CD31 protein mediates the homotypic or heterotypic cell adhesion by binding to itself or the leukocyte integrin αvβ3, and thus plays a role in neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. |
| Reference |