Human CD5L / API6 Protein (His Tag)
AIM,API6,PRO229,SP-ALPHA,Spalpha
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| Catalog Number | P10791-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | AIM,API6,PRO229,SP-ALPHA,Spalpha |
| Molecular Weight | The secreted recombinant human CD5L comprises 339 amino acids and has a predicted molecular mass of 37.5 kDa. As a result of glycosylation, rhCD5L migrates as an approximately 45 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Ser 20 |
| SDS-PAGE |  |
| Purity | > 97 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human CD5L (NP_005885.1) (Met 1-Gly 347) with a C-terminal polyhistidine tag was expressed. |
| Bio-activity | |
| Research Area | Immunology |Cluster of Differentiation (CD) |B Cell CD Antigen |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CD5L, also known as CD5 antigen-like, is a soluble protein belonging to group B of the scavenger receptor cysteine-rich (SRCR) superfamily and contains three SRCR domains. It is a secreted glycoprotein and expressed by macrophages presentin lymphoid tissues (spleen, lymph node, thymus, and bone marrow). It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram negative bacteria. and the SRCR domain 1 of CD5L retains both the LPS and LTA binding activities. In addtion, it is revealed that CD5L seems to play a role as an inhibitor of apoptosis. |
| Reference |