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Human CD81 / TAPA-1 Protein

CVID6,S5.7,TAPA1,TSPAN28

Catalog Number P14244-HNCH
Organism Species Human
Host Human Cells
Synonyms CVID6,S5.7,TAPA1,TSPAN28
Molecular Weight The recombinant human CD81 comprises 99 amino acids and has a predicted molecular mass of 9.9 kDa. The apparent molecular mass of the monomer is approximately 10 kDa in SDS-PAGE under reducing conditions.
predicted N Gly
SDS-PAGE
Purity > 90 % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the human CD81 (NP_004347.1) (Phe113-Lys201) was expressed with two additional amino acids (Gly&Pro) at the N-terminus.
Bio-activity
Research Area Immunology |Cluster of Differentiation (CD) |B Cell CD Antigen
Formulation Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background CD81, also known as TAPA-1, belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Members of this family mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.CD81 is a widely expressed cell-surface protein involved in an astonishing variety of biologic responses. It is related to adhesion, morphology, activation, proliferation, and differentiation of B, T, and other cells. On B cells CD81 is part of a complex with CD21, CD19, and Leu13. This complex reduces the threshold for B cell activation via the B cell receptor by bridging Ag specific recognition and CD21-mediated complement recognition.
Reference
  • Petracca R. et al., 2000, J Virol. 74 (10): 4824-30.
  • Bartosch B. et al., 2003, The Journal of Biological Chemistry. 278 (43): 41624-30.
  • Clark KL. et al., 2001, Journal of Immunology. 167 (9): 5115-21.