Human CEACAM3 / CD66d Protein (His Tag)
CD66D,CEA,CGM1,MGC119875,W264,W282
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Catalog Number | P11933-H08H |
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Organism Species | Human |
Host | Human Cells |
Synonyms | CD66D,CEA,CGM1,MGC119875,W264,W282 |
Molecular Weight | The recombinant human CEACAM3 consists of 132 amino acids and predictes a molecular mass of 14.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCEACAM3 is approximately 18-23 kDa due to glycosylation. |
predicted N | Lys 35 |
SDS-PAGE | |
Purity | > 95 % as determined by SDS-PAGE |
Protein Construction | A DNA sequence encoding the human CEACAM3 (NP_001806.2) extracellular domain (Met 1-Gly 155) was expressed, with a polyhistidine tag at the C-terminus. |
Bio-activity | |
Research Area | Cancer |Signal transduction |ITIM/ITAM Immunoreceptors and Related Molecules |
Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac. |
Reference |