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Human CEBPG / CEBP gamma Protein (His Tag)

GPE1BP,IG/EBP-1

Catalog Number P14925-H07E
Organism Species Human
Host E. coli
Synonyms GPE1BP,IG/EBP-1
Molecular Weight The recombinant human CEBPG consists of 124 amino acids and predicts a molecular mass of 14.1 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions.
predicted N His
SDS-PAGE
Purity > 90 % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the human CEBPG (P53567) (Pro39-Asn147) was expressed with a polyhistidine tag at the N-terminus.
Bio-activity
Research Area Cancer |Cell cycle |DNA Damage & Repair |Nucleotide Excision Repair (NER)
Formulation Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background CEBPG, also known as CEBP gamma, is a transcription factor which belongs to the CEBP family. Members of this family regulate viral and cellular CCAAT/enhancer element-mediated transcription. CEBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. CEBPG binds to the enhancer element PRE-I of the IL-4 gene. It Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites.
Reference
  • Thomassin H. et al., 1992, Nucleic Acids Res. 20 (12): 3091-8.
  • Nishizawa M. et al., 1992, FEBS Lett. 299 (1): 36-8.
  • Williams SC. et al., 1991, Genes Dev. 5 (9): 1553-67.
  • Melchionna R. et al., 2012, J Invest Dermatol. 132 (7): 1908-17.