Human CHK2/CHEK2 Protein (GST Tag)

CDS1,CHK2,hCds1,HuCds1,LFS2,PP1425,RAD53

Catalog Number	P11414-H09B
Organism Species	Human
Host	Baculovirus-Insect Cells
Synonyms	CDS1,CHK2,hCds1,HuCds1,LFS2,PP1425,RAD53
Molecular Weight	The recombinant human CHEK2 consists of 777 amino acids and predicts a molecular mass of 88.1 kDa.
predicted N	Met
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE.
Protein Construction	A DNA sequence encoding the human CHEK2 (NP_009125.1) (Met1-Leu543) was expressed with a GST tag at the N-terminus.
Bio-activity
Research Area	Cancer \|Signal transduction \|Other Related Intracellular Topics \|Cellular Senescence and Pathways in Aging \|DNA Damage and Repair
Formulation	Lyophilized from sterile 50 mM Tris, 150 mM NaCl, 25 %glycerol, pH 7.5, 0.1 mM EDTA, 0.5 mM TCEP. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Bogdanova N, et al. (2005) Association of two mutations in the CHEK2 gene with breast cancer. Cancer Genetics. 116(2) : 263-6. Dong XY, et al. (2003) Mutations in CHEK2 associated with prostate cancer risk. The American journal of human genetics. 72(2) 270-80.