Human CHST11 / C4ST-1 Protein (His Tag)
C4ST,C4ST-1,C4ST1,HSA269537
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| Catalog Number | P11396-H08B |
|---|---|
| Organism Species | Human |
| Host | Baculovirus-Insect Cells |
| Synonyms | C4ST,C4ST-1,C4ST1,HSA269537 |
| Molecular Weight | The secreted recombinant human CHST11 consists of 323 amino acids and predicts a molecular mass of 38.4 KDa. The apparent molecular mass of the protein is approximately 43 KDa in SDS-PAGE under reducing conditions. |
| predicted N | Met 36 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human CHST11 (Q9NPF2-2) (Met36-Glu347) was expressed with a C-terminal polyhistidine tag. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Metabolism |Types of disease |Metabolism in Cancer |
| Formulation | Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CHST11, also known as C4ST-1, belongs to the sulfotransferase 2 family. CHST11 localizes to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving CHST11 gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. |
| Reference |