Human CKM / CK-MM Protein (His Tag)
CKMM,M-CK
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| Catalog Number | P15076-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | CKMM,M-CK |
| Molecular Weight | The recombinant human CKM consists of 396 amino acids and predicts a molecular mass of 44.9 KDa. It migrates as an approximately 45 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human CKM (AAH07462.1) (Met1-Lys381) was expressed with a polyhistide tag at the N-terminus. |
| Bio-activity | Kinase activity untested |
| Research Area | Cancer |Invasion microenvironment |Apoptosis |Oxidative Stress |
| Formulation | Lyophilized from sterile 100mM HEPES, pH 7.0. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | CKM, also known as CK-MM, is mainly expressed in skeletal muscle. As the primary CK isoenzyme, it also can be detected in heart muscle. CKM is a subunit of creatine kinase (CK). CK is an enzyme expressed by various tissues and cell types. It catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). In the cells, the cytosolic CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). |
| Reference |