Human COMMD8 Protein (His Tag)
COMMD8
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| Catalog Number | P14666-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | COMMD8 |
| Molecular Weight | The recombinant human COMMD8 consists of 198 amino acids and predicts a molecular mass of 23 KDa. It migrates as an approximately 21-24 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human COMMD8 (AAH19826.1) (Met1-Lys183) was expressed with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Signaling |Signal Transduction |Metabolism |Pathways and Processes |Mitochondrial Metabolism |Mitophagy fission and fusion | |
| Formulation | Lyophilized from sterile 50mM Tris, 100mM NaCl, 10% Glycerol, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | COMMD8 is a member of the COMMD family. Members of this family are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. Most COMMD proteins play a role in the regulation of NF˚B and, despite their similarities, seem to function in unique and non-redundant pathways. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, copper homeostasis and in the regulation of the ubiquitin pathway. COMMD8 also contains 1 COMM domain and is widely expressed with highest expression in thyroid. |
| Reference |