Human CRABP1 / RBP5 Protein

CRABP,CRABP-I,CRABPI,RBP5

Catalog Number	P14511-HNAE
Organism Species	Human
Host	E. coli
Synonyms	CRABP,CRABP-I,CRABPI,RBP5
Molecular Weight	The recombinant human CRABP1 consists of 137 amino acids and predicts a molecular mass of 15.5 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding human CRABP1 (AAH22069.1)(Met1-Glu137) was expressed.
Bio-activity
Research Area	Signaling \|Signal Transduction \|Nuclear signaling \|Nuclear Hormone Receptor \|Retinoic & Retinoid
Formulation	Lyophilized from sterile 20mM tris , 10% glycerol, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	CRABP1 is a specific binding protein for a vitamin A family member. It is thought that CRABP1 plays an important role in retinoic acid-mediated differentiation and proliferation processes. CRABP1 is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. It forms a beta-barrel structure which accommodates hydrophobic ligands in its interior.
Reference	Wu Q. et al., 2007, Mol Cancer. 6: 45. Tanaka K. et al., 2007, Oncogene. 26 (44): 6456-68. Lind GE. et al., 2007, Cell Oncol. 28 (5-6): 259-72.