Human CRP / C-Reactive Protein (His Tag)
C-Reactive Protein,PTX1
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| Catalog Number | P11250-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | C-Reactive Protein,PTX1 |
| Molecular Weight | The secreted recombinant human CRP consists of 217 amino acids and has a predicted molecular mass of 24.7 kDa. The apparent molecular mass of rhCRP is approximately 27 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Gln 19 |
| SDS-PAGE |  |
| Purity | > 92 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human CRP (NP_000558.2) (Met 1-Pro 224) was fused with a polyhistidine tag at the C-terminus. |
| Bio-activity | Measured by its ability to bind human CD32a-His (P10374-H08B) in functional ELISA. |
| Research Area | Developmental Biology |Metabolism |Types of disease |Metabolism in Metabolic disorders |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest. |
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