Human CSEN / Calsenilin / KCNIP3 Protein (His Tag)

CSEN,DREAM,KCHIP3

Catalog Number	P14683-H07E
Organism Species	Human
Host	E. coli
Synonyms	CSEN,DREAM,KCHIP3
Molecular Weight	The recombinant human KCNIP3 consists of 271 amino acids and predicts a molecular mass of 31.1 KDa. It migrates as an approximately 29 KDa band in SDS-PAGE under reducing conditions.
predicted N	His
SDS-PAGE
Purity	> 85 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human KCNIP3 (Q9Y2W7-1) (Met1-Ile256) was expressed with a polyhistidine tag at the N-terminus.
Bio-activity
Research Area	Signaling \|Signal Transduction \|Signaling Pathway \|Calcium Signaling \|Calcium Channels
Formulation	Lyophilized from sterile 50mM Tris, 100mM NaCl, 10% Glycerol, 1mM DTT, pH 8.0. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	CSEN, also known as calsenilin and KCNIP3, is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. CSEN also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. CSEN binds to the DRE element of genes including PDYN and FOS.
Reference