Human DBH / Dopamine beta-Hydroxylase Protein (His Tag)
DBM
- 100ug (NPP2070) Please inquiry
| Catalog Number | P13440-H07H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | DBM |
| Molecular Weight | The recombinant human DBH comprises 598 amino acids and has a predicted molecular mass of 67.3 kDa. The apparent molecular mass of the protein is approximately 68 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human DBH (P09172) (Ser26-Gly603) was expressed with an N-terminal polyhistidine tag. |
| Bio-activity | |
| Research Area | Cancer |Cell cycle |Oxidative Stress |Additional Reduction/Oxidation (Redox) Enzymes |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | DBH is a 290 kDa copper-containing oxygenase. It can be detected in noradrenergic nerve terminals of the central and peripheral nervous systems, and is also expressed in chromaffin cells of the adrenal medulla. DBH contains our identical subunits, and its activity requires ascorbate as a cofactor. It functions in in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine the only transmitter synthesized inside vesicles. DBH has been shown to be associated with decision making and addictive behaviors such as alcohol and smoking, attention deficit hyperactivity disorder, and also with neurological diseases such as Schizophrenia and Alzheimer's. |
| Reference |