Human DPEP2 Protein (Fc Tag)
DPEP2
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Catalog Number | P13806-H02H |
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Organism Species | Human |
Host | Human Cells |
Synonyms | DPEP2 |
Molecular Weight | The recombinant human DPEP2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 585 amino acids and has a predicted molecular mass of 65 kDa. The apparent molecular mass of the protein is approximately 43-49 kDa in SDS-PAGE under reducing conditions. |
predicted N | Ala 33 |
SDS-PAGE | |
Purity | > 95 % as determined by SDS-PAGE |
Protein Construction | A DNA sequence encoding the human DPEP2 (AAH24021.1) (Met1-Ser376) was expressed, fused with the Fc region of human IgG1 at the C-terminus. |
Bio-activity | |
Research Area | Immunology |Signal Transduction |Metabolism |Pathways and Processes |Endocrine metabolism |Hormone biosynthesis | |
Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | DPEP2 (MBD-2) belongs to the membrane-bound dipeptidase family. There are three members of this family as membrane-bound dipeptidase-1 (MBD-1),membrane-bound dipeptidase-2 (MBD-2) and membrane-bound dipeptidase-3 (MBD-3).MBD-2 is expressed at highest levels in lung, heart, and testis and at some what lower levels in spleen.MBD-2 is membrane-bound through a glycosylphosphatidyl-inositol linkage and probably is a metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4).It is generally recognized that rapid cleavage of LTD4 is important in inactivating the broncho-and vaso-constrictive effects of cysteinyl LTs in asthmatic and inflammatory processes. |
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