Human EDEM2 / C20orf31 Protein (His Tag)
bA4204.1,C20orf31,C20orf49
- 100ug (NPP2096) Please inquiry
| Catalog Number | P15687-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | bA4204.1,C20orf31,C20orf49 |
| Molecular Weight | The recombinant human EDEM2 consists of 482 amino acids and predicts a molecular mass of 54 KDa. It migrates as an approximately 53-58 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Ala 22 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human EDEM2 (AAH01371.1) (Met1-Lys492) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Signal Transduction |Protein Trafficking |ER Proteins |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | EDEM2, also known as C20orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome. Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal. In humans there are a total of three EDEM homologs. The amino acid sequences of these proteins are different from other lectins but are closely related to the Class I mannosidases (family 47 glycosidases). EDEM2 is one of the EDEM homologs. Overexpression of EDEM2 accelerates the degradation of misfolded alpha1-antitrypsin, indicating that the protein is involved in ERAD. |
| Reference |