Human EGFL6 / EGF-L6 Protein (Flag & His Tag)
MAEG,W80
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| Catalog Number | P10867-H18B |
|---|---|
| Organism Species | Human |
| Host | Baculovirus-insect cells |
| Synonyms | MAEG,W80 |
| Molecular Weight | The recombinant human EGFL6 consists of 551 amino acids and has a calculated molecular mass of 61.5 kDa. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 65 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human EGFL6 (NP_056322.2) (Asn22-Asp553) was expressed with the flag tag at the N-terminus and the histidine tag at the C-terminus. |
| Bio-activity | Measured by the ability of the immobilized protein to support the adhesion of NIH-3T3 mouse embryonic fibroblast cells.When 5 × 10E4 cells/well areadded to CD4-coated plates (1.25μg/mL and 100μL/well),approximately 40%-60% will adhere specifically after 30 minutes at 37℃. |
| Research Area | Signaling |Signal Transduction |Metabolism |Types of disease |Metabolism in Obesity |
| Formulation | Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 20 % glycerol, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | EGFL6, also known as EGF-L6, belongs to the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. EGFL6 contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. EGFL6 gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. |
| Reference |