Human ERP72 / PDIA4 Protein (Fc Tag)
ERp-72,ERP70,ERP72
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| Catalog Number | P13333-H02H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | ERp-72,ERP70,ERP72 |
| Molecular Weight | The recombinant human PDIA4/Fc is a disulfide-linked homodimer. The reduced monomer comprises 862 amino acids and has a predicted molecular mass of 97.2 kDa. The apparent molecular mass of the protein is approximately 96 kDa in SDS-PAGE under reducing conditions |
| predicted N | Val 21 |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human PDIA4 (P13667) (Met1-Thr641) was expressed, fused with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Protein Trafficking |ER Proteins |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | ERP72, also known as PDIA4, is an endoplasmic reticulum luminal protein which belongs to the protein disulfide isomerase family. ERP72 is a stress protein and participates in the catalysis of protein-S-S-bond rearrangement. Both of PDIA4 and PDIA3 function as proteases, protein disulfide isomerases, phospholipases or an arrangement of these. ERP72 compose part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. |
| Reference |