Human FAM3C / ILEI Protein (Fc Tag)
GS3786,ILEI
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| Catalog Number | P15678-H02H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | GS3786,ILEI |
| Molecular Weight | The recombinant human FAM3C/Fc is a disulfide-linked homodimer. The reduced monomer comprises 444 amino acids and has a predicted molecular mass of 49.2 kDa. The apparent molecular mass of the protein is approximately 53 and 35 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Gln 25 |
| SDS-PAGE |  |
| Purity | (73.6+19.1) % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human FAM3C (Q92520)(Met1-Asp227) was expressed with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Signaling |Signal Transduction |Signaling Pathway |Representative pathway |MAPK singaling Pathway |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | FAM3C, also known as ILEI, is a member of the FAM3 family. It can be detected in resent in most secretory epithelia. FAM3C may be involved in retinal laminar formation. It promotes epithelial to mesenchymal transition. A change in expression of FAM3C has been noted in pancreatic cancer-derived cells. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer. |
| Reference |