Human Fetuin-B / FETUB Protein (His Tag)
16G2,Gugu,IRL685
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| Catalog Number | P11834-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | 16G2,Gugu,IRL685 |
| Molecular Weight | The recombinant human FETUB consists of 375 amino acids and predictes a molecular mass of 41.7 kDa. rhFETUB migrates as an approximately 55 kDa band in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Met 19 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human FETUB (NP_055190.2) (Met 1-Pro 382) was expressed, with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Cardiovascular |Blood |Serum Protein |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Fetuin-B, also known as Fetuin-like protein IRL685 and FETUB, is a secreted protein which belongs to the fetuin family. Fetuin-B / FETUB contains two cystatin domains. Fetuin-B is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption. Fetuin-A has been identified as a major protein during fetal life and is also involved in important functions such as protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Fetuin-A is a key partner in the recovery phase of an acute inflammatory response. Fetuin-B / FETUB is found at least in human and rodents. It is unambiguously a paralogue of Fetuin-A. Fetuin-A and Fetuin-B exhibit significant differences at the amino acid sequence level, notably including variations with respect to the archetypal fetuin-specific signature. |
| Reference |