Human GDF-15 / GDF15 Protein (His Tag) (Mature Form)
GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB
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| Catalog Number | P10936-H07Y |
|---|---|
| Organism Species | Human |
| Host | Yeast |
| Synonyms | GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB |
| Molecular Weight | The recombinant mature form of human GDF15 consists of 130 amino acids and predicts a molecular mass of 14.2 kDa. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the mature form of human GDF15 (NP_004855.2) (Ala197-Ile308) was expressed with a polyhistidine tag at the N-terminus. |
| Bio-activity | |
| Research Area | Cancer |Signal transduction |Growth Factor & Receptor |Hormones |
| Formulation | Lyophilized from sterile 35 % CAN, 0.1 % TFA. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
| Reference |