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Human GMPR / GMPR1 Protein (His Tag)

GMPR1

Catalog Number P15487-H07E
Organism Species Human
Host E. coli
Synonyms GMPR1
Molecular Weight The recombinant human GMPR consists of 360 amino acids and predicts a molecular mass of 39.2 KDa. It migrates as an approximately 37 KDa band in SDS-PAGE under reducing conditions.
predicted N His
SDS-PAGE
Purity > 85 % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the human GMPR (Met1-Ser345) was expressed with a polyhistidine tag at the N-terminus.
Bio-activity
Research Area Immunology |Signal Transduction |Other Related Intracellular Topics |Cellular Senescence and Pathways in Aging |Apoptosis |Oxidative Stress |
Formulation Lyophilized from sterile 50mM Tris, 150mM NaCl, 40% Glycerol, 1mM DTT, pH 8.0.
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background GMPR, also known as GMPR1, belongs to the IMPDH/GMPR family. This family of enzymes includes IMP dehydrogenase and GMP reductase. These enzymes are involved in purine metabolism and adopt a TIM barrel structure. GMPR is an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. GMPR functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Reference