Human GOLM1 / GP73 Protein (His Tag)

bA379P1.3,C9orf155,GOLPH2,GP73,HEL46,PSEC0257

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Catalog Number	P13066-H07E
Organism Species	Human
Host	E. coli
Synonyms	bA379P1.3,C9orf155,GOLPH2,GP73,HEL46,PSEC0257
Molecular Weight	The recombinant human GOLM1 consisting of 417 amino acids and has a calculated molecular mass of 47.4 kDa. It migrates as an 60 kDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human GOLM1 isoform 1 (Q8NBJ4-1) (Met 1-Leu 401) was expressed, with a polyhistide tag at the N-terminus.
Bio-activity
Research Area	Immunology |Signal Transduction |Protein Trafficking |Vesicle Transport |Coat Proteins
Formulation	Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	Golgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2 and GOLM1, is a protein which belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in colon, prostate, trachea and stomach. It is expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression of GOLM1 does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), GOLM1 is strongly expressed in hepatocyte-derived syncitial giant cells. GOLM1 is constitutively expressed by biliary epithelial cells but not by hepatocytes.
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