Human Galectin-3 / LGALS3 Protein, Low Endotoxin

CBP35,GAL3,GALBP,GALIG,L31,LGALS2,MAC2

Catalog Number	P10289-HNAE-E
Organism Species	Human
Host	E. coli
Synonyms	CBP35,GAL3,GALBP,GALIG,L31,LGALS2,MAC2
Molecular Weight	The recombinant human Galectin3 consisting of 250 amino acids and has a calculated molecular mass of 26.1 kDa. It migrates as an approximately 30 kDa band in SDS-PAGE under reducing conditions.
predicted N	Met 1
SDS-PAGE
Purity	> 97 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human Galectin3 (P17931) (Met 1-Ile 250) was expressed and purified.
Bio-activity	Measured by its ability to agglutinate human red blood cells. The ED₅₀ for this effect is typically 3-15 μg/ml.
Research Area	Cancer \|Signal transduction \|Cytoskeleton / ECM \|Cell Adhesion \|Lectin \|Galectin \|
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Dumic J, et al. (2006) Galectin-3: an open-ended story. Biochim Biophys Acta. 1760(4): 616-35. Sharma UC, et al. (2004) Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Circulation. 110(19): 3121-8. Yan YP, et al. (2009) Galectin-3 mediates post-ischemic tissue remodeling. Brain Res. 1288: 116-24.