Human IGSF11 / BTIGSF Protein (His Tag)
BT-IgSF, CT119, CXADRL1, Igsf13, MGC35227, VSIG3
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| Catalog Number | P13094-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | BT-IgSF, CT119, CXADRL1, Igsf13, MGC35227, VSIG3 |
| Molecular Weight | The secreted recombinant human IGSF11 consists of 229 amino acids and has a predicted molecular mass of 24.6 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 36 kDa due to glycosylation |
| predicted N | Glu 23 |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the extracellular domain of human IGSF11 (AAH34411.1) (Met 1-Gly 240) was fused with a polyhistidine tag at the C-terminus |
| Bio-activity | |
| Research Area | Epigenetics |Cell cycle |Cell Differentiation |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Immunoglobulin superfamily member 11(IGSF11) are expressed on the plasma membrane in the tesis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to over expressed in colorectal cancers and hepatocellular carcinomas as well as intestinal-type gastric cancers compared to their corresponding non- cancerous tissues. The IGSF11 has also been found expressed abundantly in testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen. |
| Reference |