Human IGSF3 / EWI-3 Protein (His Tag)
EWI-3,LCDD,V8
- 100ug (NPP2265) Please inquiry
| Catalog Number | P11290-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | EWI-3,LCDD,V8 |
| Molecular Weight | The secreted recombinant human IGSF3 comprises 1116 amino acids and has a calculated molecular mass of 126.6 kDa. The apparent molecular mass of the recombinant protein is approximately 140 kDa in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Gln 20 |
| SDS-PAGE |  |
| Purity | > 98 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human IGSF3 isoform 1 (O75054-1) extracellular domain (Met 1-Ala 1124) was expressed, with a C-terminal polyhistidine tag. |
| Bio-activity | |
| Research Area | |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Immunoglobulin superfamily member 3 (IGSF3), also known as Glu-Trp-Ile EWI motif-containing protein 3, IgSF3 and EWI-3 and IGSF3, is a single-pass type I membrane protein which belongs to the EWI subfamily of the Ig Superfamily of molecules. IGSF3 has an overall structural similarity and strong sequence similarity to V7, a human leukocyte surface protein. IGSF3 contains eight Ig-like C2-type (immunoglobulin-like) domains. IGSF3 is expressed in a wide range of tissues with high expression in Placenta, kidney and lung. EWI-2 is part of a novel Ig subfamily that includes EWI-F (F2alpha receptor regulatory protein (FPRP), CD9P-1 ), EWI-3 (IGSF3), and EWI-101 (CD101). All four members of this Ig subfamily contain a Glu-Trp-Ile (EWI) motif not seen in other Ig proteins. Human IGSF3 shares 92 % aa identity with mouse IGSF3. |
| Reference |