Human IL-1R9 / IL1RAPL2 Protein (His Tag)

IL-1R9,IL1R9,IL1RAPL-2,TIGIRR-1

100ug (NPP2270) Please inquiry

Catalog Number	P10156-H08H
Organism Species	Human
Host	Human Cells
Synonyms	IL-1R9,IL1R9,IL1RAPL-2,TIGIRR-1
Molecular Weight	The secreted recombinant human IL1R9 consists of 351 amino acids and has a predicted molecular mass of 40.7 kDa. In SDS-PAGE, the apparent molecular mass of rh IL1R9 is approximately 50-55 kDa due to glycosylation.
predicted N	Thr 17
SDS-PAGE
Purity	> 98 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the extracellular domain (Met 1-Glu 356) of human IL1R9 (NP_059112.1) was expressed, with a C-terminal polyhistidine tag.
Bio-activity
Research Area	Cancer \|Cancer immunology \|Cytokine & Receptor \|Interleukin & Receptor \|IL-1 family & Receptor \|IL-1 Family Receptor \|
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in fetal brain and is highly homologous to IL1RAPL, which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptor are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci, and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.
Reference	Jin H, et al. (2000) Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation. Eur J Hum Genet. 8(2): 87-94. Sana TR, et al. (2000) Computational identification, cloning, and characterization of IL-1R9, a novel interleukin-1 receptor-like gene encoded over an unusually large interval of human chromosome Xq22.2-q22.3. Genomics. 69(2): 252-62. Gambino F, et al. (2007) IL1-receptor accessory protein-like 1 (IL1RAPL1), a protein involved in cognitive functions, regulates N-type Ca²⁺-channel and neurite elongation. Proc Natl Acad Sci. 104(21): 9063-8.