Human IL-1RA / IL1RN Protein (Fc Tag)
DIRA,ICIL-1RA,IL-1ra,IL-1ra3,IL-1RN,IL1F3,IL1RA,IRAP,MVCD4
- 100ug (NPP4001) Please inquiry
| Catalog Number | P10123-H01H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | DIRA,ICIL-1RA,IL-1ra,IL-1ra3,IL-1RN,IL1F3,IL1RA,IRAP,MVCD4 |
| Molecular Weight | The recombinant human IL1RA/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 389 amino acids and predicts a molecular mass of 43.8 kDa. As a result of glycosylation, the rh IL1RA/Fc monomer migrates as approximately 45-55 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Glu 20 |
| SDS-PAGE |  |
| Purity | > 98 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human IL1RA (NP_776214.1) (Arg 26-Glu 177) was fused with the Fc region of human IgG1 at the N-terminus. |
| Bio-activity | |
| Research Area | Neuroscience |Neurology process |Neuroinflammation |
| Formulation | Lyophilized from sterile PBS, pH 7.2 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. A polymorphism of this protein encoding gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. IL-1RA/IL1RN may inhibit the activity of IL-1 by binding to its receptor and it has no IL-1 like activity. Genetic variation in IL-1RA/IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in IL-1RA/IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) which is also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis, and pustulosis from birth. |
| Reference |