Human IL-28B / IFN-lambda-3 Protein (His Tag)
IL-28B,IL28B,IL28C
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| Catalog Number | P11890-H08Y |
|---|---|
| Organism Species | Human |
| Host | Yeast |
| Synonyms | IL-28B,IL28B,IL28C |
| Molecular Weight | The recombinant human IFNL3 consists 189 amino acids and predicts a molecular mass of 21.3 kDa. |
| predicted N | Val 18 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE. |
| Protein Construction | A DNA sequence encoding the human IFNL3 (NP_742151.2) (Val18-Val196) was expressed with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Invasion microenvironment |Angiogenesis |Cytokine & Receptor |Interferon & Receptor |Interferon | |
| Formulation | Lyophilized from sterile PBS, PH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin-28B (IL-28B) also known as Interferon lambda-3 and IFN-lambda-3, belongs to the type III interferon family of cytokines and are highly similar to IL-29. IL-28B belongs to the newly described interferon lambda (IFNλ) family of cytokines. IL-28B is a cytokine with immunomodulatory activity. It functions in Up-regulating MHC class I antigen expression. IL-28B displays potent antiviral activity and antitumor activity. This cytokine serves as ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. IL-28B, like IL-12, is capable of robustly enhancing adaptive immunity. Moreover, we describe for the first time how IL-28B reduces regulatory T-cell populations during DNA vaccination, whereas IL-12 increases this cellular subset. We also show that IL-28B, unlike IL-12, is able to increase the percentage of splenic CD8+ T cells in vaccinated animals, and that these cells are more granular and have higher antigen-specific cytolytic degranulation compared with cells taken from animals that received IL-12 as an adjuvant. |
| Reference |