Human IL11 / Interleukin 11 / IL-11 Protein
AGIF,IL-11
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| Catalog Number | P12225-HNCE |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | AGIF,IL-11 |
| Molecular Weight | The recombinant human IL11 consists of 337 amino acids and predicts a molecular mass of 36.2 KDa. It migrates as an approximately 24 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Pro 22 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human IL11 (AAH12506.1) (Pro22-Leu199) was expressed. |
| Bio-activity | |
| Research Area | Immunology |Adaptive Immunity |B Cell |Non-CD of B cell |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | IL11 is a multifunctional cytokine first isolated in 1990 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization. |
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