Human IL11RA / IL11Rα Protein (His Tag)
CRSDA,hCG_2011440,IL11RA,MGC2146
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| Catalog Number | P10252-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CRSDA,hCG_2011440,IL11RA,MGC2146 |
| Molecular Weight | The recombinant human IL11Rαcomprises 351 amino acids and predicts a molecular mass of 38.6 kDa. As a result of glycosylation, rh IL11Rα migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Ser 24 |
| SDS-PAGE |  |
| Purity | > 97 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the extracellular domain of human IL11Rα (NP_004503.1) (Met 1-Val 363) was expressed, with a fused polyhistidine tag at the C-terminus. |
| Bio-activity | Measured by its ability to bind human IL6ST in a functional ELISA. |
| Research Area | Immunology |Signal Transduction |Jak/STAT Signaling |Receptors in the Jak/STAT Pathway |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. |
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