Human IL16 / Interleukin-16 Protein (His Tag)

FLJ16806, FLJ42735, FLJ44234, LCF, NIL16, PRIL16, prIL-16

Catalog Number	P10944-H07E
Organism Species	Human
Host	E. coli
Synonyms	FLJ16806, FLJ42735, FLJ44234, LCF, NIL16, PRIL16, prIL-16
Molecular Weight	The recombinant human IL16 consisting of 145 amino acids and has a calculated molecular mass of 15.3 kDa. It migrates as an 24 kDa band in SDS-PAGE under reducing conditions as predicted.
predicted N	Met
SDS-PAGE
Purity	> 96 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mature form of human IL16 (AAC12732.1) (Pro 2-Ser 130) was expressed, with a polyhistide tag at the N-terminus.
Bio-activity	Measured by its ability to bind recombinant human CD4-Fc in a functional ELISA.
Research Area	Immunology \|Cytokines & Growth Factors \|Cytokine & Receptor \|Interleukin & Receptor \|Other Interleukin & Receptor
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Maciaszek JW, et al. (1997) IL-16 represses HIV-1 promoter activity. J Immunol. 158(1): 5-8. Zhou P, et al. (1997) Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nat Med. 3(6): 659-64. Theodore AC, et al. (1996) CD4 ligand IL-16 inhibits the mixed lymphocyte reaction. J Immunol. 157(5): 1958-64.