Human IL17RB / IL-17 Receptor B Protein (Flag Tag)

CRL4,EVI27,IL17BR,IL17RH1

• 100ug (NPP1727) Please inquiry

Catalog Number	P13091-H25B
Organism Species	Human
Host	Baculovirus-Insect Cells
Synonyms	CRL4,EVI27,IL17BR,IL17RH1
Molecular Weight	The secreted recombinant human IL17RB comprises 280 amino acids and has a calculated molecular mass of 31 kDa. As a result of glycosylation, the apparent molecular mass of rhIL17RB is approximately 37 kDa in SDS-PAGE under reducing conditions.
predicted N	Arg 18
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the extracellular domain (Arg 18-Gly 289) of human IL17RB (NP_061195.2) was fused with a signal peptide at the N-terminus and a flag tag at the C-terminus.
Bio-activity
Research Area	Epigenetics |Cell cycle |Cell Differentiation
Formulation	Lyophilized from sterile 100mM Glycine, 10mM NaCl, pH 6.0 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310. Stock P, et al.. (2009) Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 182(8): 5116-22. Wang H, et al.. (2010) Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation. Clin Exp Allergy. 40(8): 1194-202.