Human IL17RC Protein (aa 1-454, His Tag)

IL17-RL,IL17RL

• 100ug (NPP1749) Please inquiry

Catalog Number	P11747-H08B
Organism Species	Human
Host	Baculovirus-Insect Cells
Synonyms	IL17-RL,IL17RL
Molecular Weight	The recombinant human IL17RC (aa 1-454) consists of 444 amino acids and predicts a molecular mass of 49.6 kDa. The apparent molecular mass of the protein is approximately 60 kDa in SDS-PAGE under reducing conditions.
predicted N	Leu 21
SDS-PAGE
Purity	> 90 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the full length of human IL17RC isoform 3 (NP_116121.2) (Met 1-Ala 454) was fused with a polyhistidine tag at the carboxy-terminus.
Bio-activity	1. Measured by its ability to bind with recombinant human IL17A-His (P12047-H07B) in a functional ELISA. 2. Measured by its ability to bind with recombinant human 17A (P12047-HNAE) in a functional ELISA.
Research Area	Cancer |Cancer immunology |Cytokine & Receptor |Interleukin & Receptor |IL-17 family & Receptor |IL-17 Family Receptor |
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Allen W, et al. (2010) IL-17RC: A partner in IL-17 signaling and beyond. Semin Immunopathol. 32(1): 33-42. You ZB, et al. (2007) Differential Expression of IL-17RC Isoforms in Androgen-Dependent and Androgen-Independent Prostate Cancers1. Neoplasia. 9(6): 464-70. Zrioual S, et al. (2008) IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J Immunol. 180(1): 655-63. Kuestner RE, et al. (2010) Identification of the IL-17 Receptor Related Molecule IL-17RC as the Receptor for IL-17F. J Immunol.179(8): 5462-73.