Human IL1R2 / IL1RB / CD121b Protein
CD121b,CDw121b,IL-1R-2,IL-1RT-2,IL-1RT2,IL1R2c,IL1RB
- 100ug (NPP4017) Please inquiry
| Catalog Number | P10111-HCCH |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD121b,CDw121b,IL-1R-2,IL-1RT-2,IL-1RT2,IL1R2c,IL1RB |
| Molecular Weight | The recombinant human IL1R2 consists of 336 amino acids and predicts a molecular mass of 38.4 KDa. It migrates as an approximately 49 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Phe 14 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human IL1R2 (NP_004624.1) (Met 1-Glu 343) was expressed with five amino acids (DDDDK) at the C-terminus. |
| Bio-activity | Immobilized human IL1R2 at 10 μg/ml (100 μl/well) can bind biotinylated human IL1B-His (cat:10139-H07E), The EC50 of biotinylated human IL1B-His (cat:10139-H07E) is 0.14-0.34 μg/ml. |
| Research Area | Cancer |Cancer immunology |Cytokine & Receptor |Interleukin & Receptor |IL-1 family & Receptor |IL-1 Family Receptor | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. |
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