Human IL1RL1 / DER4 Protein (Fc Tag)
DER4,FIT-1,IL33R,IL‑1 R4,ST2,ST2L,ST2V,T1
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| Catalog Number | P10105-H02H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | DER4,FIT-1,IL33R,IL‑1 R4,ST2,ST2L,ST2V,T1 |
| Molecular Weight | The recombinant human IL1RL1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 548 amino acids and has a calculated molecular mass of 67.1 kDa. As a result of glycosylation, the apparent molecular mass of rh IL1RL1/Fc monomer is approximately 85-95 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Lys 19 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human IL1RL1 isoform 2 (NP_003847.2) (Met 1-Phe 328) was fused with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | Measured by its binding ability in a functional ELISA . Immobilized human IL-33 at 10 μg/ml (100 μl/well) can bind human IL1RL1 / Fc Chimera with a linear range of 0.31-5 ng/ml. |
| Research Area | Cancer |Invasion microenvironment |Angiogenesis |Cytokines / Chemokines in Angiogenesis |Interleukins |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interlukin-1 like 1 (IL1RL1) protein can be used to diagnose cardiovascular disease and determine the prognosis for a patient with cardiovascular disease. The ligand for IL1RL1 has been described, and named IL-33. Mutants in IL1RL1 have been associated with blood eosinophil counts in a genome-wide association study and with asthma in family-based and case-control studies. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. IL33 is a specific ligand of ST2L and induces production of Th2 cytokines. |
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