Human IL20RA Protein (His Tag)
CRF2-8,IL-20R-alpha,IL-20R1,IL-20RA
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| Catalog Number | P10397-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CRF2-8,IL-20R-alpha,IL-20R1,IL-20RA |
| Molecular Weight | The recombinant human IL20Rα consists of 232 amino acids and has a calculated molecular mass of 26.8 kDa. As a result of glycosylation, rhIL20Rα migrates as an approximately 40-45 kDa protein in SDS-PAGE under reducing conditions. |
| predicted N | Val 30 |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the extracellular domain of human IL20Rα isoform 1 (NP_055247.21) (Met 1-Lys 250) was fused with a polyhistidine tag at the C-terminus. |
| Bio-activity | |
| Research Area | Cancer |Invasion microenvironment |Angiogenesis |Cytokine & Receptor |Interleukin & Receptor |IL-10 family & Receptor | |
| Formulation | Lyophilized from sterile PBS, pH 7.2 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Interleukin 20 receptor, alpha subunit (IL20RA/IL-20RA) also known as IL-20 receptor subunit alpha, Cytokine receptor class-II member 8, interleukin-20 receptor I, and interleukin-20 receptor subunit alpha, is a subunit for the interleukin-20 receptor. IL20RA/IL-20RA belongs to the type II cytokine receptor family. This cytokine is a receptor for interleukin 20 (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). IL20RA forms heterodimer with IL20RB, and the complex serves as a receptor for IL19, IL20 and IL24. All three are capable of signaling through IL-20RA/IL-20RB complex. The ligand binding to receptor B creating a high-affinity binding site for the receptor A which is recruited to complete the complex. In addition, IL20RA also forms a heterodimer with the unique and specific receptor IL10RB and functions as the receptor for IL26. IL20RA is widely expressed with highest levels in skin, testis and brain. The expression of both IL20RA and IL20RB is found to be upregulated in psoriatic skin lesions on keratinocytes. |
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