Human IL6ST / gp130 / CD130 Protein
CD130,CDW130,GP130,IL-6RB
- 100ug (NPP4022) Please inquiry
| Catalog Number | P10974-HCCH |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD130,CDW130,GP130,IL-6RB |
| Molecular Weight | The recombinant human IL6RB consists of 603 amino acids and predicts a molecular mass of 68.6 KDa. It migrates as an approximately 69-99 KDa band in SDS-PAGE under reducing conditions due to glycosylation. |
| predicted N | Glu 23 |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human IL6RB (NP_002175.2)(Met1-Ile618) was expressed with six amino acids (ENLYFQ) at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Signal Transduction |Cellular Senescence and Pathways in Aging |Apoptosis |Apoptosis Receptors |Associated Proteins | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
| Reference |