Human ILT6 / LILRA3 Protein (Fc Tag)
CD85e,HM31,HM43,ILT-6,ILT6,LIR-4,LIR4
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| Catalog Number | P13549-H02H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD85e,HM31,HM43,ILT-6,ILT6,LIR-4,LIR4 |
| Molecular Weight | The recombinant human LILRA3/Fc is a disulfide-linked homodimer. The reduced monomer comprises 657 amino acids and has a predicted molecular mass of 72 kDa. The apparent molecular mass of the protein is approximately 102 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Gly 24 |
| SDS-PAGE |  |
| Purity | > 80 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the human LILRA3 (AAH28208.1) (Met1-Glu439) was expressed, fused with the Fc region of human IgG1 at the C-terminus. |
| Bio-activity | |
| Research Area | Immunology |Signal Transduction |ITIM/ITAM Immunoreceptors and Related Molecules |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immuno-globulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease. |
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