Human ILT6 / LILRA3 Protein (His Tag)

CD85e,HM31,HM43,ILT-6,ILT6,LIR-4,LIR4

• 100ug (NPP2306) Please inquiry

Catalog Number	P13549-H08H
Organism Species	Human
Host	Human Cells
Synonyms	CD85e,HM31,HM43,ILT-6,ILT6,LIR-4,LIR4
Molecular Weight	The recombinant human LILRA3 consists of 427 amino acids and predicts a molecular mass of 46.5 KDa. It migrates as an approximately 57-66 KDa band in SDS-PAGE under reducing conditions.
predicted N	Gly 24
SDS-PAGE
Purity	> 85 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human LILRA3 (AAH28208.1) (Met1-Glu439) was expressed with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area	Immunology |Signal Transduction |ITIM/ITAM Immunoreceptors and Related Molecules
Formulation	Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	ILT6, also known as LILRA3, belongs to the ILT family. In human, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immuno-globulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.
Reference	Wi?niewski A, et al. (2004) Distribution of LILRA3 (ILT6 / LILRA3/LIR4) deletion in psoriatic patients and healthy controls. Hum Immunol. 64(4):458-61. Norman PJ, et al. (2003) DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3. Immunogenetics. 55(3):165-71. Cella M, et al. (1997) A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med. 185(10): 1743-51.