Human Interleukin-21 / IL-21 Protein
CVID11,IL-21,Za11
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Catalog Number | P10584-HNAE |
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Organism Species | Human |
Host | E. coli |
Synonyms | CVID11,IL-21,Za11 |
Molecular Weight | The recombinant human IL-21 consisting of 134 amino acids and has a calculated molecular mass of 15.6 kDa. It migrates as an approximately 17 kDa band in SDS-PAGE under reducing conditions. |
predicted N | Met |
SDS-PAGE | |
Purity | > 92 % as determined by SDS-PAGE |
Protein Construction | A DNA sequence encoding the mature form of human IL-21 isoform 1 (Q9HBE4-1) (Gln 23-Ser 155) was expressed and purified, with an initial Met. |
Bio-activity | 1. Measured by its ability to bind human IL-21R in a functional ELISA. 2. Measured by its ability to induce Interferon-gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.4-2 ng/ml. |
Research Area | Immunology |Inflammation / Inflammatory Mediator |Inflammatory Cytokines & Chemoki and Receptors |Common gamma Chain Receptor Family |
Formulation | Lyophilized from sterile 20mM NaAc, 150mM NaCl, pH 5.5 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Background | |
Reference |