Human KIM-1 / TIM1 / HAVCR1 Protein (His & Fc Tag)
CD365,HAVCR,HAVCR-1,KIM-1,KIM1,TIM,TIM-1,TIM1,TIMD-1,TIMD1
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| Catalog Number | P11051-H16H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD365,HAVCR,HAVCR-1,KIM-1,KIM1,TIM,TIM-1,TIM1,TIMD-1,TIMD1 |
| Molecular Weight | The recombinant human KIM1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 515 amino acids and predicts a molecular mass of 57 kDa. As a result of glycosylation, the apparent molecular mass of KIM1/Fc monomer is approximately 120-140 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Glu |
| SDS-PAGE |  |
| Purity | > 92 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human KIM1 extracellular domain (AAC39862.1) (Ser 21-Gly 290) was fused with a polyhistidine tag at the C-terminus and the Fc region of human IgG1 at the N-terminus. |
| Bio-activity | |
| Research Area | Immunology |Adaptive Immunity |Costimulation & Costimulatory Molecule |Other Costimulatory Molecules |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Human HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulinmucin 1 (TIM-1), is a type â… integral membrane glycoprotein. KIM-1 protein is widely expressed with highest levels in kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling. |
| Reference |