Human KLHL2 Protein (GST Tag)

ABP-KELCH,KLHL2,MAV,MAYVEN

• 100ug (NPP2293) Please inquiry

Catalog Number	P14556-H09E
Organism Species	Human
Host	E. coli
Synonyms	ABP-KELCH,KLHL2,MAV,MAYVEN
Molecular Weight	The recombinant human KLHL2 /GST chimera consists of 540 amino acids and has a predicted molecular mass of 62.2 kDa. It migrates as an approximately 63 KDa band in SDS-PAGE under reducing conditions.
predicted N	Met
SDS-PAGE
Purity	> 85 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the mature form of human KLHL2 (AAH36468.1) (Met1-Pro306) was fused with the GST tag at the N-terminus.
Bio-activity
Research Area	Cancer |Signal transduction |Cytoskeleton / ECM |Cytoskeletal Proteins |Microfilaments |Actin etc |
Formulation	Lyophilized from sterile 50mM Tris, 10% glycerol, pH 8.0 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	KLHL2 contains 1 BTB (POZ) domain and 6 Kelch repeats. It is predominantly expressed in brain. KLHL2 gene has been proposed to participate in intracellular protein transportation. KLHL2 is expected to have molecular functions such as transporter activity, actin binding and protein binding. KLHL2 localizes in various compartments such as actin cytoskeleton, cytoplasm, membrane and nucleus. It may also plays a role in organizing the actin cytoskeleton of the brain cells.
Reference	Minx P, et al. (2005) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 434:724-31. Ota T, et al. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 36:40-5. Jiang S, et al. (1999) Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell. 10:2361-75.