Human LC3A / MAP1LC3A Protein (His Tag)
ATG8E,LC3,LC3A,MAP1ALC3,MAP1BLC3
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| Catalog Number | P14322-H08E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | ATG8E,LC3,LC3A,MAP1ALC3,MAP1BLC3 |
| Molecular Weight | The recombinant human MAP1LC3A consists of 127 amino acids and predicts a molecular mass of 15.1 KDa. It migrates as an approximately 17 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | Met |
| SDS-PAGE |  |
| Purity | > 95 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human MAP1LC3A (Q9H492-1) (Met1-Phe121) was expressed with a polyhistide tag at the C-terminus. |
| Bio-activity | |
| Research Area | Developmental Biology |Metabolism |Pathways and Processes |Metabolism processes |Autophagy and mitophagy |APG gene protein | |
| Formulation | Lyophilized from sterile PBS, 10% glycerol, pH 7.5 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | LC3A, also known as MAP1LC3A, is one of the light chain subunits that functions together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. As a light chain subunit, MAP1LC3A has an important part in neuronal development and in maintaining the balance between neuronal plasticity and rigidity. MAP1LC3A is expressed as two alternatively spliced isoforms that are expressed in testis, brain, heart, liver and skeletal muscle, but are absent in thymus and peripheral blood leukocytes. |
| Reference |