Human LIFR / CD118 Protein (His Tag)
CD118,LIF-R,SJS2,STWS,SWS
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| Catalog Number | P10628-H08H |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | CD118,LIF-R,SJS2,STWS,SWS |
| Molecular Weight | The secreted recombinant human LIFR comprises 800 amino acids with a predicted molecular mass of 91 kDa. As a result of glycosylation, rhLIFR migrates as an approximately 125-135 kDa band in SDS-PAGE under reducing conditions. |
| predicted N | Gln 45 |
| SDS-PAGE |  |
| Purity | > 90 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the extracellular domain of human LIFR (NP_001121143.1) (Met 1-Ser 833) with a C-terminal polyhistidine tag was expressed. |
| Bio-activity | Measured by its ability to bind human LIF-Fc (P14890-H02H) in a functional ELISA. |
| Research Area | Neuroscience |Neurology process |Growth and Development |Neurotrophic Factor & Receptor |Other Neurotrophic Factors |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (cardiotrophin like cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1 and cardiotrophin like cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths. |
| Reference |