Human LRG1 Protein (Fc Tag)

HMFT1766,LRG

Catalog Number	P13371-H02H
Organism Species	Human
Host	Human Cells
Synonyms	HMFT1766,LRG
Molecular Weight	The recombinant human LRG1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 553 amino acids and has a predicted molecular mass of 61.3 kDa. The apparent molecular mass of the protein is approximately 65-75 kDa in SDS-PAGE under reducing conditions.
predicted N	Val 36
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human LRG1 (AAH34389.1) (Met1-Gln347) was expressed with the Fc region of human IgG1 at the C-terminus.
Bio-activity
Research Area	Cancer \|Invasion microenvironment \|Adhesion molecule \|Extracelluar matrix \|others in ECM
Formulation	Lyophilized from sterile PBS, pH 7.4. 1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	LRG1 belongs to the leucine-rich repeat (LRR) family. Members of this family are involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation. It contains 4 LIM zinc-binding domains and 1 Rho-GAP domain.
Reference	O Donnell LC. et al., 2002, J Leukoc Biol. 72 (3): 478-85. Li X. et al., 2007, Neurosci Lett. 413 (2): 141-4. Ramachandran P. et al., 2006, J Proteome Res. 5 (6): 1493-503.