Human LRP1 / A2MR / CD91 Protein (aa 786-1165)
A2MR,APOER,APR,CD91,IGFBP3R,LRP,LRP1A,TGFBR5
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| Catalog Number | P11665-HCCH |
|---|---|
| Organism Species | Human |
| Host | Human Cells |
| Synonyms | A2MR,APOER,APR,CD91,IGFBP3R,LRP,LRP1A,TGFBR5 |
| Molecular Weight | The recombinant human LRP1 (aa 786-1165) consists of 387 amino acids and predicts a molecular mass of 42 kDa. As a result of glycosylation, the apparent molecular mass of the protein is approximately 90-120 kDa in SDS-PAGE under reducing conditions. |
| predicted N | Glu 27 |
| SDS-PAGE |  |
| Purity | > 70 % as determined by SDS-PAGE |
| Protein Construction | The amino acid sequence (Arg 786-Leu 1165) of human LRP1 (NP_002323.2) corresponding to the cluster II LDLR domain was expressed and purified, with an additional peptide (ALEVLFQ) at the C-terminus. |
| Bio-activity | |
| Research Area | Cardiovascular |Atherosclerosis |Lipoprotein metabolism |
| Formulation | Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is an endocytic receptor involved in several cellular processes. LRP1 / CD91 is a member of the cluster of differentiation (CD) system. The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. LRP1 / CD91 is involved in endocytosis and in phagocytosis of apoptotic cells and is required for early embryonic development. LRP1 / CD91 is also Involved in cellular lipid homeostasis, the plasma clearance of chylomicron remnants, activated LRPAP1 (alpha 2-macroglobulin), and the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. LRP1 / CD91 May modulate cellular events, such as APP metabolism kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission need the involvement of LRP1 / CD91. |
| Reference |