Human LRP10 Protein (Fc Tag)

LRP9,MST087,MSTP087

• 100ug (NPP1643) Please inquiry

Catalog Number	P13228-H02H
Organism Species	Human
Host	Human Cells
Synonyms	LRP9,MST087,MSTP087
Molecular Weight	The secreted recombinant human LRP10/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 665 amino acids and has a predicted molecular mass of 73 kDa. The apparent molecular mass of rhLRP10/Fc monomer is approximately 80-90 kDa in SDS-PAGE under reducing conditions due to glycosylation.
predicted N	His 17
SDS-PAGE
Purity	> 88 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human LRP10 (Q7Z4F1-1) extracellular domain (Met 1-Lys 440) was fused with the Fc region of human IgG1 at the C-terminus.
Bio-activity
Research Area	Cardiovascular |Lipids / Lipoproteins |Lipoproteins/Apolipoproteins |Apolipoproteins
Formulation	Lyophilized from sterile PBS, pH 7.4 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background
Reference	Jeong YH, et al. (2010) The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway. Biochem Biophys Res Commun. 392(4): 495-9. Beisiegel U, et al. (1991) Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A. 88(19): 8342-6. Strickland DK, et al. (1990) Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem. 265(29): 17401-4.