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Human LSAMP Protein (His Tag)

FLJ34254,FLJ35396,FLJ37216,FLJ54658,IGLON3,LAMP

Catalog Number P12136-H08H
Organism Species Human
Host Human Cells
Synonyms FLJ34254,FLJ35396,FLJ37216,FLJ54658,IGLON3,LAMP
Molecular Weight The secreted mature form of recombinant human LSAMP consists of 298 amino acids and has a predicted molecular mass of 33.4 kDa. As a result of glycosylation, the apparent molecular mass of rhLSAMP is approximately 45-55 kDa in SDS-PAGE under reducing conditions.
predicted N Val 29
SDS-PAGE
Purity > 97 % as determined by SDS-PAGE
Protein Construction A DNA sequence encoding the human LSAMP (Q13449) (Met 1-Asn 315), without the pro peptide, was expressed, with a polyhistidine tag at the C-terminus.
Bio-activity
Research Area Signaling |Signal Transduction |Protein Trafficking |Organelle Proteins
Formulation Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions, also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule, serving as a guidance cue for specific patterns of connectivity, which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety, indicating a possible role of LsAMP in the regulation of anxiety.
Reference
  • Zacco A. et al., 1990, The Journal of Neuroscience. 10(1): 73-90.
  • Pimenta AF. et al., 1996, Gene. 170(2) :189-95.