Human LSM1 Protein (His Tag)
LSM1, CASM
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| Catalog Number | P14142-H07E |
|---|---|
| Organism Species | Human |
| Host | E. coli |
| Synonyms | LSM1, CASM |
| Molecular Weight | The recombinant human LSM1 consists of 148 amino acids and predicts a molecular mass of 17 KDa. It migrates as an approximately 19-21 KDa band in SDS-PAGE under reducing conditions. |
| predicted N | His |
| SDS-PAGE |  |
| Purity | > 85 % as determined by SDS-PAGE |
| Protein Construction | A DNA sequence encoding the mature form of human LSM1 (O15116) (Met1-Tyr133) was expressed with a polyhistide tag at the N-terminus. |
| Bio-activity | |
| Research Area | Epigenetics |DNA / RNA |RNA Processing |Other in RNA processing |
| Formulation | Lyophilized from sterile 10% glycerol, 20mM Tris, 100mM NaCl, pH 7.5 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
| Background | LSM1 is a Sm-like protein. Sm-like proteins can be detected in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins include the Sm sequence motif, which consists of two regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM1 has a role in replication-dependent histone mRNA degradation and binds specifically to the 3''-terminal U-tract of U6 snRNA. LSM1 also facilitates RNA protein interactions and structural modifications which are required during ribosomal subunit assembly. |
| Reference |