Human MAPRE3 / EB3 Protein (His Tag)

EB3,EBF3,EBF3-S,RP3

Catalog Number	P14614-H07E
Organism Species	Human
Host	E. coli
Synonyms	EB3,EBF3,EBF3-S,RP3
Molecular Weight	The recombinant human MAPRE3 consists of 296 amino acids and predicts a molecular mass of 33.8 KDa. It migrates as an approximately 34 KDa band in SDS-PAGE under reducing conditions.
predicted N	His
SDS-PAGE
Purity	> 95 % as determined by SDS-PAGE
Protein Construction	A DNA sequence encoding the human MAPRE3 (Q9UPY8-1) (Met1-Tyr281) was expressed with a polyhistidine tag at the N-terminus.
Bio-activity
Research Area	Immunology \|Signal Transduction \|Cytoskeleton / ECM \|Cytoskeletal Proteins \|Microtubules \|MT Associated Proteins \|
Formulation	Lyophilized from sterile PBS, 10% glycerol, pH 7.4. 1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Background	MAPRE3, also known as EB3, is a member of the RP/EB family. MAPRE3 localizes to the cytoplasmic microtubule network and binds APCL. MAPRE3 regulates the dynamics of the microtubule cytoskeleton. It also promotes microtubule growth. MAPRE3 may be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. MAPRE3 may also play a role in cell migration.
Reference	Rual JF. et al., 2005, Nature. 437 (7062): 1173-8. Yeh TY. et al., 2005, J Cell Sci. 118 (15): 3431-43. Mimori-Kiyosue Y. et al., 2005, J Cell Biol. 168 (1): 141-53.